Signs and Symptoms of Atrial Myxoma
Symptoms may occur at any time, but most often, they accompany a change of body position. Symptoms may include:
- Breathing difficulty when lying flat
- Breathing difficulty when asleep
- Chest pain or tightness
- The sensation of feeling your heartbeat (palpitations)
- Shortness of breath with activity
The symptoms and signs of left atrial myxomas often mimic mitral stenosis.
General symptoms may also be present, such as:
- Blueness of skin, especially the fingers (Raynaud’s phenomenon)
- Curvature of nails accompanied with soft tissue enlargement (clubbing) of the fingers
- Fingers that change color upon pressure or with cold or stress
- General discomfort (malaise)
- Involuntary weight loss
- Joint pain
- Swelling – any part of the body
These general symptoms may also mimic those of infective endocarditis.
Causes of Atrial Myxoma
A myxoma is a primary heart (cardiac) tumor. This means that the tumor started within the heart. Most heart tumors start somewhere else.
Primary cardiac tumors are rare. Myxomas are the most common type of these rare tumors. About 75% of myxomas occur in the left atrium of the heart, usually beginning in the wall that divides the two upper chambers of the heart. The rest are in the right atrium. Right atrial myxomas are sometimes associated with tricuspid stenosis and atrial fibrillation.
Myxomas are more common in women. About 10% of myxomas are passed down through families (inherited). Such tumors are called familial myxomas. They tend to occur in more than one part of the heart at a time and often cause symptoms at a younger age than other myxomas.
Diagnosis - Exams and Tests
The health care provider will listen to the heart with a stethoscope. A “tumor plop” (a sound related to the movement of the tumor), abnormal heart sounds, or murmur may be heard. These sounds may change when the patient changes position.
Right atrial myxomas rarely produce symptoms until they have grown to be at least 13 cm (about 5 inches) wide.
Imaging tests may include:
- Chest x-ray
- CT scan of the chest
- Doppler study
- Heart MRI
- Left heart angiography
- Right heart angiography
A complete blood count may show anemia and increased white blood cells. The erythrocyte sedimentation rate (ESR) is increased.
Treatment for Atrial Myxoma
The tumor must be surgically removed. Some patients will also need their mitral valve replaced. This can be done during the same surgery.
Although a myxoma is not cancer, complications are common. Untreated, a myxoma can lead to an embolism (tumor cells breaking off and traveling with the bloodstream), which can block blood flow or cause the myxoma to grow in another part of the body. Myxoma fragments can move to the brain, eye, or limbs.
Atrial fibrillation tends to become a chronic condition, however. It may come back even with treatment.
Prevention of Atrial Myxoma
If the tumor grows inside the heart, it can block blood flow through the mitral valve and cause symptoms of mitral stenosis. This may require emergency surgery to prevent sudden death.