New Discovery in Medicine to Help Lower Your Cholesterol

Still struggling to lower your high cholesterol?

When diet and the highest tolerated dose of a statin are not enough, adding PRALUENT® (alirocumab) could make it PLUNGE.  Some people need extra help managing their bad cholesterol. Statins can only do so much, but adding PRALUENT to the highest tolerated dose of a statin can help provide additional lowering of bad cholesterol. PRALUENT works differently than statins to lower bad cholesterol (known as LDL cholesterol). It works by blocking a protein (called PCSK9) that may contribute to high LDL cholesterol.

PRALUENT is an injectable prescription medicine called a PCSK9 inhibitor. PRALUENT is used along with diet and maximally tolerated statin therapy in adults with heterozygous familial hypercholesterolemia (an inherited condition that causes high levels of LDL i.e bad cholesterol) or atherosclerotic heart problems, who need additional lowering of LDL cholesterol.  PRALUENT is different than a statin, and is for adults with uncontrolled bad cholesterol. In clinical studies of patients with heart problems due to plaque in the arteries or with HeFH whose bad cholesterol (known as LDL cholesterol) was not at goal despite being on the highest tolerated dose of a statin, adding PRALUENT to a statin reduced high LDL cholesterol an additional 44%-58%, on average . The effect of PRALUENT on heart problems such as heart attacks, stroke, or death is not known.

How to use PRALUENT?                

See the detailed “Instructions for Use” that comes with the patient information about the right way to prepare and give your PRALUENT injections.

Use PRALUENT exactly as your doctor tells you to use it.

PRALUENT comes as a single-dose (1 time) pre-filled pen (autoinjector), or as a single-dose pre-filled syringe. Your doctor will prescribe the type and dose that is best for you.

If your doctor decides that you or a caregiver can give the injections of PRALUENT, you or your caregiver should receive training on the right way to prepare and administer PRALUENT. Do not try to inject PRALUENT until you have been shown the right way by your doctor or nurse.

PRALUENT is given as an injection under the skin (subcutaneously) 1 time every 2 weeks.

Do not inject PRALUENT together with other injectable medicines at the same injection site.

Always check the label of your pen or syringe to make sure you have the correct medicine and the correct dose of PRALUENT before each injection.

If you forget to use PRALUENT or are not able to take the dose at your regular time, inject your missed dose as soon as you remember, within 7 days of your missed dose. Then, take your next dose 2 weeks from the day you missed your dose. This will put you back on your original schedule. If the missed dose is not given within 7 days, wait until your next scheduled dose to re-start PRALUENT. This will keep you on your original schedule. If you are not sure when to restart PRALUENT, ask your doctor or pharmacist.

If you use more PRALUENT than you should, talk to your doctor or pharmacist.

Do not stop using PRALUENT without talking with your doctor. If you stop using PRALUENT, your cholesterol levels can increase.

What are the possible side effects of PRALUENT?    

The most common side effects of PRALUENT include: redness, itching, swelling, or pain/tenderness at the injection site, symptoms of the common cold, and flu or flu-like symptoms.Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all of the possible side effects of PRALUENT.

What are the ingredients in PRALUENT?

Active ingredient: alirocumab

Inactive ingredients: histidine, polysorbate 20, sucrose, and water

IMPORTANT SAFETY INFORMATION

Do not use PRALUENT if you are allergic to alirocumab or to any of the ingredients in PRALUENT.

 

PRALUENT is covered by most insurance and Medicare plans.

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